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Efficacy and Safety of a Fixed Combination of Irbesartan/Hydrochlorothiazide in Chinese Patients with Moderate to Severe Hypertension. Drugs in R&D, Jun 2013.Irbesartan is a highly potent and selective antagonist of the AT1 (angiotensin II type 1) receptor with an IC 50 = 1.3 nM. This compound has no affinity for AT2.

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